Product overview

• NameEbselen
• Short descriptionBroad enzyme inhibitor
• Biological descriptionAntioxidant and anti-inflammatory agent. Inhibits PKC, NADPH, NADPH oxidase, NO synthases, 5-lipoxygenase and cyclooxygenase. Mimics glutathione peroxidase. Shows neuroprotective and anti-cancer actions.
• Biological actionInhibitor
• Purity>98%
• Our products in actionSubmit Your Citation Now

Properties

• Chemical name2-Phenyl-1,2-benzisoselenazol-3(2H)-one
• Molecular Weight274.2
• Chemical structure
• Molecular FormulaC₁₃H₉NOSe
• CAS Number60940-34-3
• PubChem identifier3194
• SMILESC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
• InChiInChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
• InChiKeyDYEFUKCXAQOFHX-UHFFFAOYSA-N
• MDL numberMFCD00210937

Storing and Using Your Product

• Storage instructionsRoom temperature
• Solubility overviewSoluble in DMSO (100 mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ebselen

• Molecular actions of ebselen--an antiinflammatory antioxidant.

  Schewe T (1995)Gen Pharmacol 26(6) : 1153-69. PubMedID: 7590103

• Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?

  Cotgreave IA et al (1989)Biochem Pharmacol 38(4) : 649-56. PubMedID: 2537084

• Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils.

  Park S et al (2014)Free Radic Res 48(8) : 864-74. PubMedID: 24807533

• Induction of apoptosis in human multiple myeloma cell lines by ebselen via enhancing the endogenous reactive oxygen species production.

  Zhang L et al (2014)Biomed Res Int 2014 : 696107 PubMedID: 24587987