Product overview

• Name3-Methyladenine
• Short descriptionPI-3K inhibitor
• Biological descriptionPhosphoinositide 3-kinase (PI-3K) inhibitor. Inhibits autophagy, modulates endosomal membrane trafficking and stimulates adipocyte PKA-dependent lipolysis. May potentiate the action of anticancer drugs.
• Biological actionInhibitor
• Purity>99%
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Properties

• Chemical name3-Methyl-3H-purin-6-amine
• Molecular Weight149.15
• Molecular FormulaC₆H₇N₅
• CAS Number5142-23-4

Storing and Using Your Product

• Storage instructions+4°C
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 3-Methyladenine

• 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism.

  Caro et al (1988)Eur J Biochem 175(2) : 325-9 PubMedID: 3402459

• 3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy.

  Sheng et al (2013)Biochem Biophys Res Commun. 432(1) : 5-9 PubMedID: 23395679

• 3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN.

  Hirosako et al (2004)Biochem Biophys Res Commun 316(3) : 845-52 PubMedID: 15033478