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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > 您好Bio/(±;)-K湾8644/HB1209/
商品详细您好Bio/(±;)-K湾8644/HB1209/
您好Bio/(±;)-K湾8644/HB1209/
您好Bio/(±;)-K湾8644/HB1209/
商品编号: HB1209
品牌: hellobio
市场价: ¥585.00
美元价: 450.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Productoverview

  • Name
    (±)-BayK8644
  • Shortdescription
    L-typeCa2+channelagoNIST.AidsiPSCsgenerationfromMouseembryonicfibroblasts.
  • BIOLOGicaldescription
    L-typeCa2+channelagonist.Causesreducedinotropyinthemyocardium.Alsoaidsinducedpluripotentstemcellgenerationfrommouseembryonicfibroblasts(MEFs).Showsconvulsiveandvasoconstrictiveactions.
  • Biologicalaction
    Agonist
  • Purity
    >99%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylicacid,methylester
  • MolecularWeight
    356.3
  • Chemicalstructure
    (±)-Bay K 8644 [71145-03-4]
  • MolecularFormula
    C16H15F3N2O4
  • CASNumber
    71145-03-4

StoringandUsingYourProduct

  • Storageinstructions
    +4°C
  • Solubilityoverview
    solubleinethanol(100mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

Referencesfor(±)-BayK8644

  • ReducedeffectsofBAYK8644onL-typeCa2+currentinfailinghumancardiacmyocytesarerelatedtoabnormaladrenergicregulation.

    ChenXetal(2008)AmJPhysiolHeartCircPhysiol294(5):H2257-67.
    PubMedID:18359894
  • ActivationofproteinkinaseCby1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-pyridinecarboxylicacidmethylester(BayK8644),acalciumchannelagonist,inalveolartypeIIcells.

    SenNetal(1997)BiochemPharmacol53(9):1307-13.
    PubMedID:9214691
  • DimemorfanpreventsseizuresinducedbytheL-typecalciumchannelactivatorBAYk-8644inmice.

    ShinEJetal(2004)BehavBrainRes151(1-2):267-76.
    PubMedID:15084442
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor,  NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632,  SB 431542 DAPT.