Product overview

• Name(R,S)-MCPG sodium salt
• Short descriptionWater soluble, non-selective group I and II mGluR antagonist
• Biological description

  Water soluble non-selective group I and II mGluR antagonist.

  Also competitive antagonist of ACPD sensitive receptors.

  Shows no effect on locomotor activity.

  (R,S)-MCPG and (S)-MCPG sodium salt also available. (S)-MCPG also available.

• Biological actionAntagonist
• Purity>98%
• Our products in actionSubmit Your Citation Now

Properties

• Chemical name(RS)-α-Methyl-4-carboxyphenylglycine disodium salt
• Molecular Weight253.16
• Chemical structure
• Molecular FormulaC₁₀H₉NNa₂O₄
• CAS Number1303994-09-3
• SMILESNC(C)(C(=O)O[Na])c1ccc(cc1)C(=O)O
• SourceSynthetic
• AppearanceWhite solid

Storing and Using Your Product

• Storage instructionsRoom temperature
• Solubility overviewSoluble in water (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (R,S)-MCPG sodium salt

• The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats.

  Kim JH et al (1998)Neuropharmacology 37(2) : 189-97. PubMedID: 9680243

• MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus.

  Manzoni OJ et al (1994)Eur J Neurosci 6(6) : 1050-4. PubMedID: 7952274

• Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.

  Eaton SA et al (1993)Eur J Pharmacol 244(2) : 195-7. PubMedID: 8381746