Product overview

• Name(R,S)-CHPG
• Short descriptionSelective mGlu₅ agonist
• Biological description

  Selective mGlu₅ receptor agonist which shows no activity at mGlu₁. Potentiates NMDA-induced depolarizations in rat hippocampal slices. Active in vivo. Water soluble CHPG sodium salt also available.

• Alternative names(R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
• Biological actionAgonist
• Purity>98%
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Properties

• Chemical name(R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
• Molecular Weight201.61
• Chemical structure
• Molecular FormulaC₈H₈NO₃Cl
• CAS Number170846-74-9
• PubChem identifier3645780
• SMILESC1=CC(=C(C=C1O)C(C(=O)O)N)Cl
• SourceSynthetic
• InChiInChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
• InChiKeyUNIDAFCQFPGYJJ-UHFFFAOYSA-N
• MDL numberMFCD01321059
• AppearanceOff-white solid

Storing and Using Your Product

• Storage instructions+4°C (desiccate)
• Solubility overviewSoluble in 0.1M NaOH (100 mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (R,S)-CHPG

• (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.

  Doherty AJ et al (1997)Neuropharmacology 36(2) : 265-7. PubMedID: 9144665

• Activation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells.

  Dai SH et al (2014)Int J Mol Sci 15(6) : 10892-907. PubMedID: 24941251

• The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway.

  Chen T et al (2012)Int J Mol Med 29(4) : 630-6. PubMedID: 22211238

• Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices.

  Fazal A et al (2003)J Neurochem 86(6) : 1346-58. PubMedID: 12950444