Product overview

• NameJX 401
• Short descriptionPotent, reversible p38α MAPK inhibitor
• Biological descriptionPotent and reversible p38α MAPK inhibitor (IC₅₀ = 32 nM) that isnt ATP-competitive. Membrane permeable. Exhibits little or no activity at p38γ. Inhibits Elk1 phosphorylation. Displays anti-inflmmatory properties.
• Biological actionInhibitor
• Purity>98%
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Properties

• Chemical name1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
• Molecular Weight355.49
• Molecular FormulaC₂₁H₂₅NO₂S
• CAS Number349087-34-9

Storing and Using Your Product

• Storage instructionsroom temperature
• Solubility overviewsoluble in DMSO (75mM) or ethsnol (50mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for JX 401

• JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast.

  Friedmann Y et al (2006)Mol Pharmacol 70(4) : 1395-405. PubMedID: 16847144