Product overview

• NameArctigenin
• Short descriptionPotent MAP kinase kinase (MKK/MEK) inhibitor
• Biological descriptionPotent MAP kinase kinase (MKK/MEK) inhibitor (IC₅₀ = 1 nM for MKK1/MEK1). Antiviral, anti-cancer, antioxidant and anti-inflammatory compound. Inhibits iNOS expression by suppressing 1-κBα phosphorylation and nuclear translocation of p65 (IC₅₀ = 10 nM). Shows neuroprotective actions.
• Biological actionInhibitor
• Purity>98%
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Properties

• Chemical name(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
• Molecular Weight372.42
• Chemical structure
• Molecular FormulaC₂₁H₂₄O₆
• CAS Number7770-78-7

Storing and Using Your Product

• Storage instructions-20°C (desiccate)
• Solubility overviewsoluble in ethanol (25mM, gentle warming) or DMSO (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Arctigenin

• Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.

  Jang YP et al (2002)J Neurosci Res 68(2) : 233-40. PubMedID: 11948668

• Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages.

  Cho MK et al (2002)Int Immunopharmacol 2(1) : 105-16. PubMedID: 11789661

• Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis.

  Yang S et al (2012)Anat Rec (Hoboken) 295(8) : 1260-6. PubMedID: 22619087

• Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition.

  Cho MK et al (2004)4(10-11) : 1419-29 PubMedID: 15313439