Hello Bio/IDRA 21/HB0334/
市场价：
¥1384.50
美元价：
1065.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameIDRA21
- ShortdescriptionAMPAreceptorpositiveallostericmodulator
- BIOLOGicaldescriptionAMPAreceptorpositiveallostericmodulator.EnhanceslongtermpotentiationandinhibitsAMPAreceptordesensitization.Increasesexcitatorysynapticstrength.Displayspositiveeffectsoncognitioninseveralanimalmodels.Bloodbrainbarrierpermeable.
- BiologicalactionPAM
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiADIazineS,S-dioxide
- MolecularWeight232.68
- MolecularFormulaC8H9ClN2O2S
- CASNumber22503-72-6
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforIDRA21
TheeffectsofhuperzineAandIDRA21onvisualrecognitionmemoryinyoungmacaques.
MalkovaLetal(2011)Neuropharmacology60(7-8):1262-8.PubMedID:211853137-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide:apartialmodulatorofAMPAreceptordesensitizationdevoidofneurotoxicity.
ImpagnatielloFetal(1997)ProcNatlAcadSciUSA94(13):7053-8.PubMedID:91926907-Chloro-3-methyl-3-4-dihydro-2H-1,2,4benzothiadiazineS,S-dioxide(IDRA21):abenzothiadiazinederivativethatenhancescognitionbyattenuatingDL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoicacid(AMPA)receptordesensitization.
ZivkovicIetal(1995)JPharmacolExpTher272(1):300-9.PubMedID:7815345
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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