Hello Bio/ZM 447439/HB1444/10mg
市场价：
¥3276.00
美元价：
2520.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameZM447439
- ShortdescriptionPotent,selective,ATP-competitiveAurorakinaseBinhibitor
- BIOLOGicaldescriptionPotent,selectiveandATP-competitiveAurorakinaseBinhibitor(IC50valuesare50,250and1000nMforAurorakinaseB,CandArespectively).Inhibitsmitoticchromosomealignment,mitoticsegregationandcytokinesis.Showsanti-proliferativeandanti-canceractions.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
- MolecularWeight513.59
- Chemicalstructure
![ZM 447439 [331771-20-1]](images/hellobio/201710/hb1444.png "ZM 447439 [331771-20-1]")
- MolecularFormulaC29H31N5O4
- CASNumber331771-20-1
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforZM447439
AuroraBcoupleschromosomealignmentwithanaphasebytargetingBubR1,Mad2,andCenp-Etokinetochores.
DitchfieldCetal(2003)JCellBiol161(2):267-80.PubMedID:12719470ValidatingAuroraBasananti-cancerdrugtarget.
GirdlerFetal(2006)JCellSci119(Pt17):3664-75.PubMedID:16912073ZM447439,theAurorakinaseBinhibitor,suppressesthegrowthofcervicalcancerSiHacellsandenhancesthechemosensitivitytocisplatin.
ZhangLetal(2011)JObstetGynaecolRes37(6):591-600.PubMedID:21159048
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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