Hello Bio/Doxorubicin hydrochloride/HB4183/50mg
市场价：
¥6279.00
美元价：
4830.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameDoxorubicinhydrochloride
- ShortdescriptionAntibiotic.DNAtopisomeraseIIinhibitor.
- BIOLOGicaldescription
AntibioticandDNAtopisomeraseIIinhibitor.
IntercalatesintoDNAtoinhibitnucleicacidsynthesis.
Inducesapoptosisandshowsantitumorandanti-neoplasticactivity
- AlternativenamesAdriamycin,NSC123127,DOX,DXR
- BiologicalactionAntibiotic
- ApplicationsAntineoplasticAgent
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname10-[(3-Amino-2,3,6-trideoxy-?-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedionehydrochloride
- MolecularWeight579.99
- MolecularFormulaC27H29NO11.HCl
- CASNumber25316-40-9
- PubChemidentifier443939
- SMILESC[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl
- InChiKeyMWWSFMDVAYGXBV-RUELKSSGSA-N
- MDLnumberMFCD00077757
- AppearanceOrange
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(50mM)andwater(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDoxorubicinhydrochloride
IdentificationofyeastDNAtopoisomeraseIImutantsresistanttotheantitumordrugdoxorubicin:implicationsforthemechanismsofdoxorubicinactionandcytotoxicity.
Pateletal(1997)MolPharmacol52(4):658-66PubMedID:9380029Studiesontheinvitroreactivityofclofibrylandfenofibrylglucuronides.EvidenceforproteinbindingviaaSchiff"sbasemechanism.
Grubbetal(1993)BiochemPharmacol46(3):357-64PubMedID:8347161
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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