Hello Bio/Doxorubicin hydrochloride/HB4183/10mg
市场价：
¥1482.00
美元价：
1140.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameDoxorubicin hydrochloride
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Short descriptionAntibiotic. DNA topisomerase II inhibitor.
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Biological description
Antibiotic and DNA topisomerase II inhibitor.
Intercalates into DNA to inhibit nucleic acid synthesis.
Induces apoptosis and shows antitumor and anti-neoplastic activity
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Alternative namesAdriamycin, NSC 123127, DOX, DXR
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Biological actionAntibiotic
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ApplicationsAntineoplastic Agent
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name10-[(3-Amino-2,3,6-trideoxy-?-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
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Molecular Weight579.99
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Molecular FormulaC27H29NO11.HCl
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CAS Number25316-40-9
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PubChem identifier443939
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SMILESC[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl
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InChiKeyMWWSFMDVAYGXBV-RUELKSSGSA-N
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MDL numberMFCD00077757
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AppearanceOrange
Storing and Using Your Product
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Storage instructionsRoom temperature
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Solubility overviewSoluble in DMSO (50 mM) and water (50 mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Doxorubicin hydrochloride
Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity.
Patel et al (1997) Mol Pharmacol 52(4) : 658-66PubMedID: 9380029Studies on the in vitro reactivity of clofibryl and fenofibryl glucuronides. Evidence for protein binding via a Schiff's base mechanism.
Grubb et al (1993) Biochem Pharmacol 46(3) : 357-64PubMedID: 8347161
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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