Hello Bio/Z-VAD-(OMe)-FMK/HB1319/5mg
市场价：
¥8385.00
美元价：
6450.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameZ-VAD-(OMe)-FMK
- ShortdescriptionIrreversIBLe,cellpermeable,broadspectrumcaspaseinhibitor.
- BIOLOGicaldescriptionIrreversible,cellpermeable,broadspectrumcaspaseinhibitor.AlsoinhibitsPARP-1cleavageandFas-inducedapoptosis.HydrolysedbyendogenousesterasesintothebiologicallyactiveformZ-VAD-FMK.
- BiologicalactionInhibitor
- Purity>95%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameBenzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
- MolecularWeight467.48
- Chemicalstructure
![Z-VAD-(OMe)-FMK [187389-52-2]](images/hellobio/201710/hb_1319.png "Z-VAD-(OMe)-FMK [187389-52-2]")
- MolecularFormula
C22H30FN3O7
- CASNumber187389-52-2
- PubChemidentifier5497174
- SMILESC[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
- InChiInChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
- InChiKeyMIFGOLAMNLSLGH-QOKNQOGYSA-N
- MDLnumberMFCD01074990
- AppearanceWhitesolid
StoringandUsingYourProduct
- Storageinstructions-20°C
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforZ-VAD-(OMe)-FMK
AmyloidprecursorproteinbindingproteinFe65iscleavedbycaspasesduringDNAdamage-inducedapoptosis.
SaekiKetal(2011)BiolPharmBull34(2):290-4.PubMedID:21415543Benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethylketone(Z-VAD.FMK)inhibitsapoptosisbyblockingtheprocessingofCPP32.
SleeEAetal(1996)BiochemJ315(Pt1):21-4.PubMedID:8670109Aspecificinhibitorofapoptosisdecreasestissueinjuryafterintestinalischemia-reperfusioninmice.
FarberAetal(1999)JVascSurg30(4):752-60.PubMedID:10514215
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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