Hello Bio/Z-VAD-(OMe)-FMK/HB1319/1mg
市场价：
¥3510.00
美元价：
2700.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameZ-VAD-(OMe)-FMK
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Short descriptionIrreversible, cell permeable, broad spectrum caspase inhibitor.
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Biological descriptionIrreversible, cell permeable, broad spectrum caspase inhibitor. Also inhibits PARP-1 cleavage and Fas-induced apoptosis. Hydrolysed by endogenous esterases into the biologically active form Z-VAD-FMK.
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Biological actionInhibitor
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Purity>95%
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Properties
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Chemical nameBenzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
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Molecular Weight467.48
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Chemical structure
![Z-VAD-(OMe)-FMK [187389-52-2]](images/hellobio/201710/hb_1319.png "Z-VAD-(OMe)-FMK [187389-52-2]")
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Molecular Formula
C22H30FN3O7
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CAS Number187389-52-2
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PubChem identifier5497174
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SMILESC[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
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InChiInChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
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InChiKeyMIFGOLAMNLSLGH-QOKNQOGYSA-N
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MDL numberMFCD01074990
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AppearanceWhite solid
Storing and Using Your Product
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Storage instructions-20°C
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Z-VAD-(OMe)-FMK
Amyloid precursor protein binding protein Fe65 is cleaved by caspases during DNA damage-induced apoptosis.
Saeki K et al (2011) Biol Pharm Bull 34(2) : 290-4.PubMedID: 21415543Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.
Slee EA et al (1996) Biochem J 315 ( Pt 1) : 21-4.PubMedID: 8670109A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice.
Farber A et al (1999) J Vasc Surg 30(4) : 752-60.PubMedID: 10514215
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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