Hello Bio/Z-VAD-FMK/HB1285/1mg
市场价：
¥3724.50
美元价：
2865.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameZ-VAD-FMK
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Short descriptionBroad spectrum caspase inhibitor
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Biological descriptionBroad spectrum caspase inhibitor. Blocks apoptosis and activation of caspases during Fas-L induced apoptosis. Also Inhibits T-cell proliferation displaying immunosuppressive properties.
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Alternative namesZVAD-FMK; Z-VAD.FMK
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Biological actionInhibitor
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Properties
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Chemical nameBenzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
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Molecular Weight467.49
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Chemical structure
![Z-VAD-FMK [187389-52-2]](images/hellobio/201710/hb1285.png "Z-VAD-FMK [187389-52-2]")
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Molecular FormulaC22H30FN3O7
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CAS Number187389-52-2
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PubChem identifier5497174
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SMILESC[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
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InChiInChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
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InChiKeyMIFGOLAMNLSLGH-QOKNQOGYSA-N
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MDL numberMFCD01074990
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewSoluble in DMSO (20 mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Z-VAD-FMK
Radiation-induced cytochrome c release and the neuroprotective effects of the pan-caspase inhibitor z-VAD-fmk in the hypoglossal nucleus.
Li J et al (2014) Exp Ther Med 7(2) : 383-388.PubMedID: 24396410Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties.
Lawrence CP et al (2012) Toxicol Appl Pharmacol 265(1) : 103-12.PubMedID: 22982538Inhibition of human caspases by peptide-based and macromolecular inhibitors.
Garcia-Calvo M et al (1998) J Biol Chem 273(49) : 32608-13.PubMedID: 9829999Correlation of tumor necrosis factor alpha (TNF alpha) with high Caspase 3-like activity in myelodysplastic syndromes.
Mundle SD et al (1999) Cancer Lett 140(1-2) : 201-7.PubMedID: 10403560
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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