Hello Bio/Zoniporide dihydrochloride/HB1137/50mg
市场价：
¥11193.00
美元价：
8610.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameZoniporidedihydrochloride
- ShortdescriptionPotent,selectiveNa+/H+exchanger-1inhibitor
- BIOLOGicaldescriptionPotentandselectiveNa+/H+exchanger-1(NHE-1)inhibitor(IC50=14nM).Exhibits157-foldand15,700-foldselectivityforNHE1overhumanNHE-2andratNHE-3respectively.Displayscardioprotectivepropertiesandreducesboththeincidenceanddurationofischemia-reperfusion.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname[1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidinedihydrochloride
- MolecularWeight393.27
- Chemicalstructure
![Zoniporide dihydrochloride [241799-10-0]](images/hellobio/201710/hb1137.png "Zoniporide dihydrochloride [241799-10-0]")
- MolecularFormulaC17H16N6O.2HCl
- CASNumber241799-10-0
StoringandUsingYourProduct
- Storageinstructions-20°C
- Solubilityoverviewsolubleinwater(10mM)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforZoniporidedihydrochloride
Zoniporide:apotentandhighlyselectiveinhibitorofhumanNa(+)/H(+)exchanger-1.
MaralaRBetal(2002)EurJPharmacol451(1):37-41.PubMedID:12223226[Cardioprotectivepropertiesofzoniporidestudiedonexperimentalischemiaandreperfusionmodelsinratmyocardium].
GurovaNAetal(2013)EkspKlinFarmakol76(8):17-9.PubMedID:24228483Zoniporide:apotentandselectiveinhibitorofthehumansodium-hydrogenexchangerisoform1(NHE-1).
TraceyWRetal(2003)CardiovascDrugRev21(1):17-32.PubMedID:12595915
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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