Hello Bio/Z-Leu-Leu-Leu-B(OH)2/HB4134/200μg
市场价：
¥4270.50
美元价：
3285.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameZ-Leu-Leu-Leu-B(OH)2
- ShortdescriptionHighlypotent,selective,cellpermeableproteasomeinhibitor.MorepotentthanMG-132.
- BIOLOGicaldescriptionHighlypotent,selective,reversIBLecellpermeableproteasomeinhibitor.MorepotentthanMG-132.Inhibitschymotrypsin-andcaspase-likepeptidaseactivityoftheproteasome.Alsoshowscalpainandcathepsininhibitor.Activatesautophagyandinducesapoptosis.
- AlternativenamesMG-262|ZL3B|Z-LLL-B(OH)2
- BiologicalactionInhibitor
- Purity>95%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameZ-Leu-Leu-Leu-B(OH)2
- MolecularWeight491.4
- MolecularFormulaC25H42BN3O6
- CASNumber179324-22-2
- InChiKeyMWKOOGAFELWOCD-FKBYEOEOSA-N
- AppearanceSolidlyophilizedpowder
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforZ-Leu-Leu-Leu-B(OH)2
AntimalarialactivityoftheanticancerandproteasomeinhibitorbortezomibanditsanalogZL3B.
ReynoldsJMetal(2007)BMCClinPharmacol.23:7-13PubMedID:http://www.ncbi.nlm.nih.gov/pubmProteasomeinhibitionreducesproliferation,collagenexpression,andinflammatorycytokineproductioninnasalmucosaandpolypfibroblasts.
PujolsLetal(2012)JPharmacolExpTher343(1):184-97PubMedID:22787116IdentificationoftheproteasomeinhibitorMG262asapotentATP-dependentinhibitoroftheSalmonellaentericaSEROvarTyphimuriumLonprotease.
FraseHetal(2006)Biochemistry45(27):8264-74PubMedID:16819825Preventingproteostasisdiseasesbyselectiveinhibitionofaphosphataseregulatorysubunit.
DasIetal(2015)Science348(6231):239-42PubMedID:25859045
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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