Hello Bio/Z-DEVD-FMK/HB1282/5mg
市场价：
¥16068.00
美元价：
12360.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameZ-DEVD-FMK
- ShortdescriptionIrreversIBLe,selectivecaspase3inhibitor
- BIOLOGicaldescriptionIrreversibleandselectivecaspase3inhibitor(IC50=0.13µM).Cellpermeable.ExhibitsnoactivityatcathespinBandcathespinL.Displaysneuroprotectivepropertiesandinhibitsapoptosis.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameBenzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
- MolecularWeight668.67
- MolecularFormulaC30H41FN4O12
- CASNumber210344-95-9
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(13.37mg/ml)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforZ-DEVD-FMK
ApoptosisofNG108-15cellsinducedbybuprenorphinehydrochlorideoccursviathecaspase-3pathway.
KugawaFetal(2000)BiolPharmBull23(8):930-5.PubMedID:10963298Involvementofcaspase-3-likeproteaseinthemechanismofcelldeathfollowingfocallyevokedlimbicseizures.
HenshallDCetal(2000)JNeuRochem74(3):1215-23.PubMedID:10693954Identificationofapoptosis-associatedproteinsinahumanBurkittlymphomacellline.CleavageofheterogeneousnuclearribonucleoproteinA1bycaspase3.
BrockstedtEetal(1998)JBiolChem273(43):28057-64.PubMedID:9774422Developmentofnear-infraredfluorophore(NIRF)-labeledactivity-basedprobesforinvivoimagingoflegumain.
LeeJetal(2010)ACSChemBiol5(2):233-43.PubMedID:20017516
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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