Hello Bio/ZD 7288/HB1152/50mg
市场价：
¥6688.50
美元价：
5145.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameZD7288
- ShortdescriptionHCNchannelblocker.Modulatessino-atrialnodefunction.
- BIOLOGicaldescription
Hyperpolarization-activated,cyclicnucleotide-gatedcation(HCN)channelblocker(IC50=15.0µM).
Modulatessino-atrialnodefunction;blocksthehyperpolarization-activatedinwardcurrentIfandinhibitsIhincentralneurons.
AlsoinhibitsNa+currentsindorsalrootganglionneurons(IC50=1.17µM).
Blockslongtermpotentiation(LTP)inductionanddisplaysanxiolyticproperties.
Alsoincreasesdoublingtimeofembryonicstemcells(ESCs)andmodulatesdifferentiationoutcomes.Activeinvivo.
- BiologicalactionBlocker
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidiniumchloride
- MolecularWeight292.81
- Chemicalstructure
![ZD 7288 [133059-99-1]](images/hellobio/201710/hb1152.png "ZD 7288 [133059-99-1]")
- MolecularFormulaC15H21ClN4
- CASNumber133059-99-1
- PubChemidentifier123983
- SMILESCCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
- SourceSynthetic
- InChiInChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
- InChiKeyDUWKUHWHTPRMAP-UHFFFAOYSA-N
- MDLnumberMFCD16879001
- AppearanceWhitesolid
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewSolubleinwater(100mM)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforZD7288
IsZD7288aselectiveblockerofhyperpolarization-activatedcyclicnucleotide-gatedchannelcurrents?
WuXetal(2012)Channels(Austin)6(6):438-42.PubMedID:22989944IntrahippocampalinfusionoftheIhblockerZD7288slowsevokedthetarhythmandproducesanxiolytic-likeeffectsintheelevatedplusmaze.
YeungMetal(2013)Hippocampus23(4):278-86.PubMedID:23280856InhibitoryactionsofZENECAZD7288onwhole-cellhyperpolarizationactivatedinwardcurrent(If)inguinea-pigdissociatedsinoatrialnodecells.
BoSmithREetal(1993)BrJPharmacol110(1):343-9.PubMedID:7693281ZD7288,ablockeroftheHCNchannelfamily,increasesdoublingtimeofmouseembryonicstemcellsandmodulatesdifferentiationoutcomesinacontext-dependentmanner.
Omelyanenkoetal(2016)Springerplus16:5:41PubMedID:26835223
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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