Hello Bio/ZD 7288/HB1152/10mg
市场价：
¥1599.00
美元价：
1230.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameZD 7288
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Short descriptionHCN channel blocker. Modulates sino-atrial node function.
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Biological description
Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 15.0 µM).
Modulates sino-atrial node function; blocks the hyperpolarization-activated inward current If and inhibits Ih in central neurons.
Also inhibits Na+ currents in dorsal root ganglion neurons (IC50 = 1.17 µM).
Blocks long term potentiation (LTP) induction and displays anxiolytic properties.
Also increases doubling time of embryonic stem cells (ESCs) and modulates differentiation outcomes. Active in vivo.
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Biological actionBlocker
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
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Molecular Weight292.81
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Chemical structure
![ZD 7288 [133059-99-1]](images/hellobio/201710/hb1152.png "ZD 7288 [133059-99-1]")
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Molecular FormulaC15H21ClN4
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CAS Number133059-99-1
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PubChem identifier123983
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SMILESCCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
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SourceSynthetic
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InChiInChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
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InChiKeyDUWKUHWHTPRMAP-UHFFFAOYSA-N
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MDL numberMFCD16879001
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AppearanceWhite solid
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewSoluble in water (100mM) or DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for ZD 7288
Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?
Wu X et al (2012) Channels (Austin) 6(6) : 438-42.PubMedID: 22989944Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.
Yeung M et al (2013) Hippocampus 23(4) : 278-86.PubMedID: 23280856Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.
BoSmith RE et al (1993) Br J Pharmacol 110(1) : 343-9.PubMedID: 7693281ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.
Omelyanenko et al (2016) Springerplus 16 : 5:41PubMedID: 26835223
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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