你好Bio/YM 298198盐酸盐/HB0664/
市场价：
¥955.50
美元价：
735.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameYM 298198 hydrochloride
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Short descriptionPotent, selective, non-competitive mGlu1 antagonist
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Biological descriptionPotent, selective and non-competitive mGlu1 receptor antagonist (IC50 = 16 nM). Shows antiproliferative effects in cancers expressing mGlu1 receptor.
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Alternative namesYM 298198
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Biological actionAntagonist
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Purity>99%
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Properties
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Chemical name6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
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Molecular Weight378.92
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Chemical structure
![YM 298198 hydrochloride [748758-45-4]](images/hellobio/201710/hb0664.png "YM 298198 hydrochloride [748758-45-4]")
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Molecular FormulaC18H22N4OS.HCl
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CAS Number748758-45-4
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PubChem identifier45073464
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SMILESCC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl
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InChiInChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
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InChiKeyWYTJVUVCSUWZTH-UHFFFAOYSA-N
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MDL numberMFCD08703122
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewSoluble in water (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for YM 298198 hydrochloride
Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor ty
Kohara A et al (2005) J Pharmacol Exp Ther 315(1) : 163-9.PubMedID: 15976016Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
Fukunaga I et al (2007) Br J Pharmacol 151(6) : 870-6.PubMedID: 17502847Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.
Speyer CL et al (2014) PLoS One 9(3) : e88830.PubMedID: 24633367
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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