Hello Bio/YM 298198 hydrochloride/HB0664/50mg
市场价：
¥11388.00
美元价：
8760.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameYM298198hydrochloride
- ShortdescriptionPotent,selective,non-competitivemGlu1antagoNIST
- BIOLOGicaldescriptionPotent,selectiveandnon-competitivemGlu1receptorantagonist(IC50=16nM).ShowsantiproliferativeeffectsincancersexpressingmGlu1receptor.
- AlternativenamesYM298198
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamidehydrochloride
- MolecularWeight378.92
- Chemicalstructure
![YM 298198 hydrochloride [748758-45-4]](images/hellobio/201710/hb0664.png "YM 298198 hydrochloride [748758-45-4]")
- MolecularFormulaC18H22N4OS.HCl
- CASNumber748758-45-4
- PubChemidentifier45073464
- SMILESCC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl
- InChiInChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
- InChiKeyWYTJVUVCSUWZTH-UHFFFAOYSA-N
- MDLnumberMFCD08703122
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewSolubleinwater(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforYM298198hydrochloride
RADIoligandbindingpropertiesandpharmacologicalcharacterizationof6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide(YM-298198),ahigh-affinity,selective,andnoncompetitiveantagonistofmetabotropicglutamatereceptorty
KoharaAetal(2005)JPharmacolExpTher315(1):163-9.PubMedID:15976016PotentandspecificactionofthemGlu1antagonistsYM-298198andJNJ16259685onsynaptictransmissioninratcerebellarslices.
FukunagaIetal(2007)BrJPharmacol151(6):870-6.PubMedID:17502847Metabotropicglutamatereceptor-1asanoveltargetfortheantiangiogenictreatmentofbreastcancer.
SpeyerCLetal(2014)PLoSOne9(3):e88830.PubMedID:24633367
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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