你好Bio/XE 991二盐酸盐/HB1090/50mg
市场价：
¥9789.00
美元价：
7530.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameXE991dihydrochloride
- ShortdescriptionPotent,selectiveKv7channelblocker
- BIOLOGicaldescriptionPotentandselectiveKv7(KCNQ)channelblocker.InhibitsKCNQtypeIM(M-current),Kv4.3andKv1.2(IC50valuesare0.71,>43and>100µM).BlocksKCNQ1current(Kd=78µM).EnhancesAChrelease(EC50=490nM).Showscognitiveenhancingactions.
- BiologicalactionBlocker
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenonedihydrochloride
- MolecularWeight449.37
- Chemicalstructure
![XE 991 dihydrochloride [122955-42-4]](images/hellobio/201710/hb1090.png "XE 991 dihydrochloride [122955-42-4]")
- MolecularFormulaC26H20N2O.2HCl
- CASNumber122955-42-4
- PubChemidentifier45073462
- SMILESC1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl
- InChiInChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H
- InChiKeyWOGWMARIFDNZON-UHFFFAOYSA-N
- MDLnumberMFCD05662331
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforXE991dihydrochloride
Twonewpotentneurotransmitterreleaseenhancers,10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenoneand10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone:comparisontolinopirdine.
ZaczekRetal(1998)JPharmacolExpTher285(2):724-30.PubMedID:9580619CharacterizationofM-currentinventraltegmentalareadopamineneurons.
KoyamaSetal(2006)JNeurophysiol96(2):535-43.PubMedID:16394077MolecularbasisfordifferentialsensitivityofKCNQandI(Ks)channelstothecognitiveenhancerXE991.
WangHSetal(2000)MolPharmacol57(6):1218-23.PubMedID:10825393TheM-currentinhibitorXE991decreasesthestimulationthresholdforlong-termsynapticplasticityinhealthymiceandinmodelsofcognitivedisease.
Fontán-LozanoAetal(2011)Hippocampus21(1):22-32.PubMedID:19921704
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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