Hello Bio/XE 991 dihydrochloride/HB1090/10mg
市场价：
¥2437.50
美元价：
1875.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameXE 991 dihydrochloride
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Short descriptionPotent, selective Kv7 channel blocker
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Biological descriptionPotent and selective Kv7 (KCNQ) channel blocker. Inhibits KCNQ type IM (M-current), Kv4.3 and Kv1.2 (IC50 values are 0.71, >43 and>100 µM).Blocks KCNQ1 current (Kd = 78 µM). Enhances ACh release (EC50 = 490 nM). Shows cognitive enhancing actions.
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Biological actionBlocker
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Purity>99%
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Properties
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Chemical name10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
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Molecular Weight449.37
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Chemical structure
![XE 991 dihydrochloride [122955-42-4]](images/hellobio/201710/hb1090.png "XE 991 dihydrochloride [122955-42-4]")
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Molecular FormulaC26H20N2O.2HCl
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CAS Number122955-42-4
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PubChem identifier45073462
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SMILESC1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl
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InChiInChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H
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InChiKeyWOGWMARIFDNZON-UHFFFAOYSA-N
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MDL numberMFCD05662331
Storing and Using Your Product
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Storage instructionsRoom temperature (desiccate)
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Solubility overviewSoluble in water (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for XE 991 dihydrochloride
Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.
Zaczek R et al (1998) J Pharmacol Exp Ther 285(2) : 724-30.PubMedID: 9580619Characterization of M-current in ventral tegmental area dopamine neurons.
Koyama S et al (2006) J Neurophysiol 96(2) : 535-43.PubMedID: 16394077Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.
Wang HS et al (2000) Mol Pharmacol 57(6) : 1218-23.PubMedID: 10825393The M-current inhibitor XE991 decreases the stimulation threshold for long-term synaptic plasticity in healthy mice and in models of cognitive disease.
Fontán-Lozano A et al (2011) Hippocampus 21(1) : 22-32.PubMedID: 19921704
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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