Hello Bio/XAV 939/HB0660/5mg
市场价：
¥897.00
美元价：
690.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameXAV939
- ShortdescriptionPotenttankyraseinhibitor.Wnt/β-cateninsignalinginhibitor.
- BIOLOGicaldescription
Potenttankyrase(TNKS)inhibitor(IC50valuesare4and11nMatTNKS2andTNKS1respectively).
XAV939stABIlizesAxintostimulateβ-catenindegradationtoinhibittheWnt-β-cateninsignallingpathway.
Displaysantiproliferativeandapoptoticinducingproperties.Alsoinvolvedinneuronaldevelopment.
Robustlyinducescardiomyogenesisinmouseembryonicstem(ES)cells.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
- MolecularWeight312.31
- Chemicalstructure
![XAV 939 [284028-89-3]](images/hellobio/201710/hb0660.png "XAV 939 [284028-89-3]")
- MolecularFormulaC14H11F3N2OS
- CASNumber284028-89-3
- PubChemidentifier2726824
- SMILESC1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
- SourceSynthetic
- InChiInChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
- InChiKeyKLGQSVMIPOVQAX-UHFFFAOYSA-N
- MDLnumberMFCD16879017
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforXAV939
XAV939inhibitsthestemnessandmigrationofneuroblastomacancerstemcellsviarepressionoftankyrase1.
TianXetal(2014)IntJOncol45(1):121-8.PubMedID:24789807Modellingofatargetednanotherapeutic"stroma"todeliverthecytokineLIF,orXAV939,apotentinhibitorofWnt-β-cateninsignalling,foruseinhumanfetaldopaminergicgraftsinParkinson"sdisease.
ZhaoJWetal(2014)DisModelMech7(10):1193-203.PubMedID:25085990Structureofhumantankyrase1incomplexwithsmall-moleculeinhibitorsPJ34andXAV939.
KirbyCAetal(2012)ActaCrystallogrSectFStructBiolCrystCommun68(Pt2):115-8.PubMedID:22297980XAV939,atankyrase1inhibitior,promotescellapoptosisinneuroblastomacelllinesbyinhibitingWnt/β-cateninsignalingpathway.
TianXHetal(2013)JExpClinCancerRes32:100PubMedID:24308762
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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