你好Bio/XAP044/HB1599/50mg
市场价：
¥9633.00
美元价：
7410.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameXAP044
- ShortdescriptionNovel,selectivemGlu7antagoNIST
- BIOLOGicaldescriptionNovel,selectivemGlu7receptorantagonist.Showsnovelmolecularmodeofpharmacologicalaction.ActsasanorthostericlikeantagonistandbindsatabindingpocketintheVenusflytrapdomain.Inhibitslongtermpotentiation(LTP)inthelateralamygdalainamGlu7dependentmanner(IC50=88nM).Showsanti-stress,anxiolyticandanti-depressantactions.Blood-brainbarrierpermeable.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
- MolecularWeight380.13
- Chemicalstructure
![XAP 044 [196928-50-4]](images/hellobio/201710/hb1599.png "XAP 044 [196928-50-4]")
- MolecularFormulaC15H9IO4
- CASNumber196928-50-4
- PubChemidentifier5428913
- SMILESC1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
- InChiInChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
- InChiKeyXXZKJJYWINSUMJ-UHFFFAOYSA-N
- MDLnumberMFCD00525548
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforXAP044
Blockingmetabotropicglutamatereceptorsubtype7(mGlu7)viatheVenusflytrapdomain(VFTD)inhibitsamygdalaplasticity,stress,andanxiety-relatedbehavior.
GeeCEetal(2014)JBiolChem289(16):10975-87.PubMedID:24596089
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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