Hello Bio/Wnt-C59/HB3155/
市场价：
¥585.00
美元价：
450.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameWnt-C59
- ShortdescriptionHighlypotentPORCNinhibitor.InducesiPSCcardiomyocytesdifferentiation.
- BIOLOGicaldescriptionPotent,cellpermeablePORCNinhibitor(IC50=74pM).>100-foldmorepotentthanIWP1.PotentlyinhibitsWnt/β-cateninsignaling.Alsoinducesinducedpluripotentstemcell(iPSC)cardiomyocytedifferentiationwhenusedincombinationwithCHIR99021.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide
- MolecularWeight379.45
- Chemicalstructure
![Wnt-C59 | [1243243-89-1]](images/hellobio/201710/hb3155.png "Wnt-C59 | [1243243-89-1]")
- MolecularFormulaC25H21N3O
- CASNumber1243243-89-1
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(20mM)orethanol(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforWnt-C59
PharmacologicalinhibitionoftheWntacyltransferasePORCNpreventsgrowthofWNT-drivenmammarycancer.
Proffittetal(2013)CancerRes73(2):502-7PubMedID:23188502Adultinterfolliculartumour-initiatingcellsarereprogrammedintoanembryonichairfollicleProgenitor-likefateduringbasalcellcarcinomainitiation.
Youssefetal(24930130)NatCellBiol14(12):1282-94PubMedID:24930130Smallmolecule-mediateddisruptionofWnt-dependentsignalingintissueregenerationandcancer.
Chenetal(2009)NatChemBiol5(2):100-7PubMedID:19125156
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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