Hello Bio/WIKI4/HB0657/5mg
市场价：
¥1189.50
美元价：
915.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameWIKI4
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Short descriptionPotent tankyrase inhibitor. Wnt signaling inhibitor.
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Biological descriptionPotent tankyrase (TNKS) inhibitor (IC50 values are 15 and 26 nM for TNKS2 and TNKS1 respectively). Inhibits the auto-ADP-ribosylation of tankyrase and Wnt/β-catenin signaling in cancer cell lines and embryonic stem cells (EC50 = 75 nM).
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyr idinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz [de]isoquinoline-1,3(2H)-dione
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Molecular Weight521.59
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Chemical structure
![WIKI4 [838818-26-1]](images/hellobio/201710/hb0657.png "WIKI4 [838818-26-1]")
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Molecular FormulaC29H23N5O3S
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CAS Number838818-26-1
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewsoluble in DMSO (20mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for WIKI4
WIKI4, a novel inhibitor of tankyrase and Wnt/ã?-catenin signaling.
James RG et al (2012) PLoS One 7(12) : e50457.PubMedID: 23227175Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4.
Haikarainen T et al (2013) PLoS One 8(6) : e65404.PubMedID: 23762361
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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