Hello Bio/WHI-P 154/HB1431/
市场价：
¥585.00
美元价：
450.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameWHI-P 154
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Short descriptionNon-selective JAK3 inhibitor and potent EGFR inhibitor. Induces neural progenitor cell differentiation.
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Biological descriptionNon-selective JAK3 inhibitor (IC50 = 1.8 µM), also acts as a potent EGFR kinase inhibitor (IC50 = 4 nM). Inhibits expression of iNOS and production of NO. Also induces neural progenitor cell differentiation. Shows apoptotic and anti-tumor actions.
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Alternative namesWHI-P154
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
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Molecular Weight376.2
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Chemical structure
![WHI-P 154 [211555-04-3]](images/hellobio/201710/hb1431.png "WHI-P 154 [211555-04-3]")
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Molecular FormulaC16H14BrN3O3
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CAS Number211555-04-3
Storing and Using Your Product
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Storage instructionsroom temperature
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Solubility overviewsoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for WHI-P 154
The specificity of JAK3 kinase inhibitors.
Changelian PS et al (2008) Blood 111(4) : 2155-7.PubMedID: 18094329Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha.
Sareila O et al (2008) Int Immunopharmacol 8(1) : 100-8.PubMedID: 180681054-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells.
Narla RK et al (1998) Clin Cancer Res 4(6) : 1405-14.PubMedID: 9626456
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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