Hello Bio/WHI-P 154/HB1431/5mg
市场价：
¥1267.50
美元价：
975.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameWHI-P154
- ShortdescriptionNon-selectiveJAK3inhibitorandpotentEGFRinhibitor.InducesneuralProgenitorcelldifferentiation.
- BIOLOGicaldescriptionNon-selectiveJAK3inhibitor(IC50=1.8µM),alsoactsasapotentEGFRkinaseinhibitor(IC50=4nM).InhibitsexpressionofiNOSandproductionofNO.Alsoinducesneuralprogenitorcelldifferentiation.Showsapoptoticandanti-tumoractions.
- AlternativenamesWHI-P154
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
- MolecularWeight376.2
- Chemicalstructure
![WHI-P 154 [211555-04-3]](images/hellobio/201710/hb1431.png "WHI-P 154 [211555-04-3]")
- MolecularFormulaC16H14BrN3O3
- CASNumber211555-04-3
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforWHI-P154
ThespecificityofJAK3kinaseinhibitors.
ChangelianPSetal(2008)Blood111(4):2155-7.PubMedID:18094329Januskinase3inhibitorWHI-P154inmacrophagesactivatedbybacterialendotoxin:differentialeffectsontheexpressionofiNOS,COX-2andTNF-alpha.
SareilaOetal(2008)IntImmunopharmacol8(1):100-8.PubMedID:180681054-(3"-Bromo-4"hydroxylphenyl)-amino-6,7-dimethoxyquinazoline:anovelquinazolinederivativewithpotentcytotoxicactivityagainsthumanglioblastomacells.
NarlaRKetal(1998)ClinCancerRes4(6):1405-14.PubMedID:9626456
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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