你好Bio/VX 745/HB1309/50mg
市场价:
¥11134.50
美元价:
8565.00
产品分类:
酸碱缓冲液
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Productoverview
- NameVX745
- ShortdescriptionPotent,selectivep38αMAPKinhibitor
- BIOLOGicaldescriptionPotentandselectivep38αMAPKinhibitor.Exhibits20-foldselectivityforp38αoverp38β(Ki=200nM).ShowslittleornoactivityatotherMAPkinases.InhibitsTNFαandIL-1β(IC50valuesare45and51nMrespectively).Displaysanti-inflammatoryproperties.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one
- MolecularWeight436.26
- MolecularFormulaC19H9Cl2F2N3OS
- CASNumber209410-46-8
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforVX745
TheDiscoveryofVX-745:ANovelandSelectivep38αKinaseInhibitor.
DuffyJPetal(2011)ACSMedChemLett2(10):758-63.PubMedID:24900264RapidsynthesisofVX-745:p38MAPkinaseinhibitioninWernersyndromecells.
BagleyMCetal(2007)BioorgMedChemLett17(18):5107-10.PubMedID:17659871
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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