Hello Bio/VX 702/HB1308/10mg
市场价：
¥2086.50
美元价：
1605.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameVX702
- ShortdescriptionPotent,selectiveATP-competitivep38MAPKinhibitor
- BIOLOGicaldescriptionPotentandselectiveATP-competitivep38MAPKinhibitor(Kdvaluesare3.7and17nMforp38αandp38βrespectively).AlsoinhibitsproductionofIL-6,IL-1βandTNFα(IC50valuesare59,122and99ng/mlrespectively).ExhibitsnoactivityforERKsandJNKsDisplaysanti-inflammatoryproperties.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
- MolecularWeight404.32
- MolecularFormulaC19H12F4N4O2
- CASNumber479543-46-9
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforVX702
Selectivep38alphainhibitorsclinicallyevaluatedforthetreatmentofchronicinflammatorydisorders.
GoldsteinDMetal(2010)JMedChem53(6):2345-53.PubMedID:19950901Aninhibitionofp38mitogenactivatedproteinkinasedelaystheplateletstoragelesion.
SkripchenkoAetal(2013)PLoSOne8(8):e70732.PubMedID:23967093Drugevaluation:VX-702,aMAPkinaseinhibitorforrheumatoidarthritisandacutecoronarysyndrome.
DingC(2006)CurrOpinInvestigDrugs7(11):1020-5.PubMedID:17117592
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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