Hello Bio/Valproic acid sodium salt/HB0867/10g
市场价：
¥682.50
美元价：
525.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameValproicacidsodiumsalt
- ShortdescriptionHistonedeacetylaseinhibitor.ShowsmultitudeofBIOLOGicalactions.Enablespluripotentstemcellinductionfromsomaticcells.
- BiologicaldescriptionHistonedeacetylaseinhibitor(IC50=400µMatHDAC1).Showsmultitudeofbiologicalactions.Canbeusedtoproducepluripotentstemcells(iPScells)withonlyOct4andSox2factorsrequiredinaddition.ActivatesWnt-dependentgeneexpressionandshowsanti-inflammatory,anti-canceranti-epilepticandneuroprotectiveactions.Blood-brainbarrierpermeable.
- AlternativenamesVPA
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameSodium2-propylpentanoate
- MolecularWeight166.19
- Chemicalstructure
![Valproic acid sodium salt [1069-66-5]](images/hellobio/201710/hb0867.png "Valproic acid sodium salt [1069-66-5]")
- MolecularFormulaC8H15NaO2
- CASNumber1069-66-5
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- Solubilityoverviewsolubleinwater(100mM)orDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforValproicacidsodiumsalt
Histonedeacetylaseisadirecttargetofvalproicacid,apotentanticonvulsant,moodstABIlizer,andteratogen.
PhielCJetal(2001)JBiolChem276(39):36734-41.PubMedID:11473107ValproicacidinhibitsAbetaproduction,neuriticplaqueformation,andbehavioraldeficitsinAlzheimer"sdiseasemousemodels.
QingHetal(2008)JExpMed205(12):2781-9.PubMedID:18955571Potentiationofanticancereffectofvalproicacid,anantiepilepticagentwithhistonedeacetylaseinhibitoryactivity,bythecyclin-dependentkinaseinhibitorP276-00inhumannon-small-celllungcancercelllines.
ShirsathNetal(2013)LungCancer82(2):214-21.PubMedID:24051085InductionofpluripotentstemcellsfromprimaryhumanfibroblastswithonlyOct4andSox2.
HuangfuDetal(2008)NatBiotechnol26(11):1269-75.PubMedID:18849973
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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