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商品详细Hello Bio/UNC 0224/HB1420/50mg
Hello Bio/UNC 0224/HB1420/50mg
Hello Bio/UNC 0224/HB1420/50mg
商品编号: HB1420
品牌: hellobio
市场价: ¥11134.50
美元价: 8565.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Product overview

  • Name
    UNC 0224
  • Short description
    Potent, selective G9a HMTase inhibitor
  • Biological description
    Potent and selective G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 = 15 nM).
  • Alternative names
    Compound 8
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action
    Submit Your Citation Now

Properties

  • Chemical name
    7-[3-(Dimethylamino)propoxy]-2-(hex ahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N- (1-methyl-4-piperidinyl)-4-quinazolinamine
  • Molecular Weight
    485.67
  • Chemical structure
    UNC 0224  [1197196-48-7]
  • Molecular Formula
    C26H43N7O2
  • CAS Number
    1197196-48-7

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for UNC 0224

  • Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

    Liu F et al (2009) J Med Chem 52(24) : 7950-3.
    PubMedID: 19891491
  • Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

    Liu F et al (2010) J Med Chem 53(15) : 5844-57.
    PubMedID: 20614940
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor,  NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632,  SB 431542 DAPT.