Hello Bio/UNC 0224/HB1420/10mg
市场价：
¥2847.00
美元价：
2190.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameUNC 0224
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Short descriptionPotent, selective G9a HMTase inhibitor
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Biological descriptionPotent and selective G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 = 15 nM).
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Alternative namesCompound 8
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name7-[3-(Dimethylamino)propoxy]-2-(hex ahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N- (1-methyl-4-piperidinyl)-4-quinazolinamine
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Molecular Weight485.67
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Chemical structure
![UNC 0224 [1197196-48-7]](images/hellobio/201710/hb1420.png "UNC 0224 [1197196-48-7]")
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Molecular FormulaC26H43N7O2
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CAS Number1197196-48-7
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for UNC 0224
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
Liu F et al (2009) J Med Chem 52(24) : 7950-3.PubMedID: 19891491Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
Liu F et al (2010) J Med Chem 53(15) : 5844-57.PubMedID: 20614940
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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