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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > Hello Bio/UCPH 101/HB0630/25mg
商品详细Hello Bio/UCPH 101/HB0630/25mg
Hello Bio/UCPH 101/HB0630/25mg
Hello Bio/UCPH 101/HB0630/25mg
商品编号: HB0630
品牌: hellobio
市场价: ¥3627.00
美元价: 2790.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Product overview

  • Name
    UCPH 101
  • Short description
    UCPH 101 is a potent, selective, non-competitive EAAT1 inhibitor
  • Biological description
    UCPH 101 is a potent, selective, non-competitive EAAT1 inhibitor (IC50 = 660 nM). UCPH 101 shows >400-fold selectivity for EAAT1 over EAAT2 and EAAT3 and shows no inhibitory activity at EAAT4 and EAAT5 in a patch-clamp electrophysiology assay (in which final concentration was up to 10 μM).
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action
    Submit Your Citation Now

Properties

  • Chemical name
    2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene- 3-carbonitrile
  • Molecular Weight
    422.48
  • Chemical structure
    UCPH 101  [1118460-77-7]
  • Molecular Formula
    C27H22N2O3
  • CAS Number
    1118460-77-7

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for UCPH 101

  • Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.

    Jensen AA et al (2009) J Med Chem 52(4) : 912-5.
    PubMedID: 19161278
  • Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.

    Huynh TH et al (2012) Bioorg Med Chem 20(23) : 6831-9.
    PubMedID: 23072958
  • Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.

    Abrahamsen B et al (2013) J Neurosci 33(3) : 1068-87.
    PubMedID: 23325245
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor,  NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632,  SB 431542 DAPT.