Hello Bio/UCPH 101/HB0630/10mg
市场价：
¥2866.50
美元价：
2205.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
-
NameUCPH 101
-
Short descriptionUCPH 101 is a potent, selective, non-competitive EAAT1 inhibitor
-
Biological descriptionUCPH 101 is a potent, selective, non-competitive EAAT1 inhibitor (IC50 = 660 nM). UCPH 101 shows >400-fold selectivity for EAAT1 over EAAT2 and EAAT3 and shows no inhibitory activity at EAAT4 and EAAT5 in a patch-clamp electrophysiology assay (in which final concentration was up to 10 μM).
-
Biological actionInhibitor
-
Purity>98%
-
Our products in actionSubmit Your Citation Now
Properties
-
Chemical name2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene- 3-carbonitrile
-
Molecular Weight422.48
-
Chemical structure
![UCPH 101 [1118460-77-7]](images/hellobio/201710/hb0630.png "UCPH 101 [1118460-77-7]")
-
Molecular FormulaC27H22N2O3
-
CAS Number1118460-77-7
Storing and Using Your Product
-
Storage instructions+4°C
-
Solubility overviewsoluble in DMSO (25mM)
-
ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for UCPH 101
Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.
Jensen AA et al (2009) J Med Chem 52(4) : 912-5.PubMedID: 19161278Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.
Huynh TH et al (2012) Bioorg Med Chem 20(23) : 6831-9.PubMedID: 23072958Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.
Abrahamsen B et al (2013) J Neurosci 33(3) : 1068-87.PubMedID: 23325245
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
