Hello Bio/UBP 310/HB0628/
市场价：
¥1989.00
美元价：
1530.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameUBP310
- ShortdescriptionPotent,selectiveGluK1/GluK3subunitselectivekainatereceptorantagoNIST
- BIOLOGicaldescriptionPotentandselectiveGluK1(formerlyGluR5)andGluK3(formerlyGluR7)subunitselectivekainatereceptorantagonist(Kb=10nMandIC50=23nMrespectively).IC50valuesare>100µMforGluA2,GluK6,GluK2/3andGluK6/GluK2respectively.ActiveatAMPAreceptorsandinactiveagainstNMDAandGroupImGlureceptorsatconcentrationsofupto10µM.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
- MolecularWeight353.35
- Chemicalstructure
![UBP 310 [902464-46-4]](images/hellobio/201710/hb0628.png "UBP 310 [902464-46-4]")
- MolecularFormulaC14H15N3O6S
- CASNumber902464-46-4
- PubChemidentifier6420160
- SMILESCC1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)C[C@@H](C(=O)O)N
- InChiInChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h4-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
- InChiKeyZTAZUCRXCRXNSU-VIFPVBQESA-N
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewSolubleinDMSO
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforUBP310
CrystalstructuresofthekainatereceptorGluR5ligandbindingcoredimerwithnovelGluR5-selectiveantagonists.
MayerMLetal(2006)JNeurosci26(11):2852-61.PubMedID:16540562SynthesisandpharmacologicalcharacterizationofN3-substitutedwillardiinederivatives:roleofthesubstituentatthe5-positionoftheuracilringinthedevelopmentofhighlypotentandselectiveGLUK5kainatereceptorantagonists.
DolmanNPetal(2007)JMedChem50(7):1558-70.PubMedID:17348638AntagonismofrecombinantandnativeGluK3-containingkainatereceptors.
PerraisDetal(2009)Neuropharmacology56(1):131-40.PubMedID:18761361
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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