Hello Bio/UBP 310/HB0628/10mg
市场价：
¥2242.50
美元价：
1725.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameUBP 310
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Short descriptionPotent, selective GluK1 / GluK3 subunit selective kainate receptor antagonist
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Biological descriptionPotent and selective GluK1 (formerly GluR5) and GluK3 (formerly GluR7) subunit selective kainate receptor antagonist (Kb = 10 nM and IC50 = 23 nM respectively). IC50 values are > 100 µM for GluA2, GluK6, GluK2/3 and GluK6/GluK2 respectively. Active at AMPA receptors and inactive against NMDA and Group I mGlu receptors at concentrations of up to 10 µM.
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Biological actionAntagonist
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name(S)-1-(2-Amino-2-carboxyethyl)-3-(2 -carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
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Molecular Weight353.35
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Chemical structure
![UBP 310 [902464-46-4]](images/hellobio/201710/hb0628.png "UBP 310 [902464-46-4]")
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Molecular FormulaC14H15N3O6S
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CAS Number902464-46-4
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PubChem identifier6420160
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SMILESCC1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)C[C@@H](C(=O)O)N
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InChiInChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h4-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
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InChiKeyZTAZUCRXCRXNSU-VIFPVBQESA-N
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewSoluble in DMSO
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for UBP 310
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
Mayer ML et al (2006) J Neurosci 26(11) : 2852-61.PubMedID: 16540562Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.
Dolman NP et al (2007) J Med Chem 50(7) : 1558-70.PubMedID: 17348638Antagonism of recombinant and native GluK3-containing kainate receptors.
Perrais D et al (2009) Neuropharmacology 56(1) : 131-40.PubMedID: 18761361
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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