Hello Bio/U0126/HB2246/25mg
市场价：
¥11134.50
美元价：
8565.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameU0126
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Short descriptionPotent, selective MEK-1/MEK-2 inhibitor
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Biological descriptionPotent, selective and non-competitive MAP kinase kinase (MAP2K) inhbitor. Inhibits both MEK-1 and MEK-2 (IC50 values are 72 and 58 nM respectively) while showing little or no effect on many other kinases. Inhibits AP-1 transactivation and shows many other actions. Active in vivo.
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Biological actionInhibitor
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Purity>99%
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Our products in action1 citation Submit Your Citation Now
Images
Properties
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Chemical name1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
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Molecular Weight380.48
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Chemical structure
![U0126 [109511-58-2]](images/hellobio/201710/hb2246.png "U0126 [109511-58-2]")
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Molecular FormulaC18H16N6S2
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CAS Number109511-58-2
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PubChem identifier3006531
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SMILESC1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)N)/C#N)C#N)/N
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InChiInChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
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InChiKeyDVEXZJFMOKTQEZ-JYFOCSDGSA-N
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MDL numberMFCD25977152
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewSoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for U0126
MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.
Duncia JV et al (1998) Bioorg Med Chem Lett 8(20) : 2839-44.PubMedID: 9873633Identification of a novel inhibitor of mitogen-activated protein kinase kinase.
Favata MF et al (1998) J Biol Chem 273(29) : 18623-32.PubMedID: 9660836Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model.
Duan W et al (2004) J Immunol 172(11) : 7053-9.PubMedID: 15153527Pre-LTP requires extracellular signal-regulated kinase in the ACC.
Yamanaka et al (2016) Mol Pain 12 : 1-12PubMedID: 27178245
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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