Hello Bio/TX-1123/HB0622/50mg
市场价：
¥9048.00
美元价：
6960.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTX-1123
- ShortdescriptionTyrosinekinaseinhibitor
- BIOLOGicaldescriptionTyrosinekinaseinhibitor.InhibitsSrc,eEF2-K,andPKA(IC50valuesare2.2,3.2and9.6mMrespectively).Showsanti-tumoractionsandactsasanantiangiogenichypoxiccellrADIosensitizer.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-((3,5-di-tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione
- MolecularWeight312.4
- Chemicalstructure
![TX-1123 [157397-06-3]](images/hellobio/201710/hb0622.png "TX-1123 [157397-06-3]")
- MolecularFormulaC20H24O3
- CASNumber157397-06-3
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(10mg/ml)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTX-1123
TX-1123:anantitumor2-hydroxyarylidene-4-cyclopentene-1,3-dioneasaproteintyrosinekinaseinhibitorhavinglowmitochondrialtoxicity.
HoriHetal(2002)BioorgMedChem10(10):3257-65.PubMedID:12150871Designofhypoxia-targetingproteintyrosinekinaseinhibitorusinganinnovativepharmacophore2-methylene-4-cyclopentene-1,3-dione.
HoriHetal(2004)BiochimBiophysActa1697(1-2):29-38.PubMedID:15023348Chemicalpropertiesandbiologicalactivitiesofcyclopentenediones:areview.
SevcíkováZetal(2014)MiniRevMedChem14(4):322-31.PubMedID:24605879
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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