你好Bio/Tubacin/HB1403/5mg
市场价：
¥14332.50
美元价：
11025.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTubacin
- ShortdescriptionSelectiveHDAC6inhibitor
- BIOLOGicaldescriptionSelectivehistonedeacetylase6(HDAC6)inhibitor.SelectiveforHDAC6overHDAC3,8,1,5,10,11,9,2,7and4(IC50valuesare4nMand1.27,1.27,1.4,3.35,3.71,3.79,4.31,6.27,9.7and17.3µMrespectively).Inducestubulinacetylation.Showsanti-cancer,anti-proliferativeandapoptoticactions.
- AlternativenamesTubulinacetylationinducer
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N"-hydroxyoctanediamide
- MolecularWeight721.86
- Chemicalstructure
![Tubacin [1350555-93-9]](images/hellobio/201710/hb1403.png "Tubacin [1350555-93-9]")
- MolecularFormulaC41H43N3O7S
- CASNumber1350555-93-9
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTubacin
Rationaldesignandsimplechemistryyieldasuperior,neuroprotectiveHDAC6inhibitor,tubastatinA.
ButlerKVetal(2010)JAmChemSoc132(31):10842-6.PubMedID:20614936Domain-selectivesmall-moleculeinhibitorofhistonedeacetylase6(HDAC6)-mediatedtubulindeacetylation.
HaggartySJetal(2003)ProcNatlAcadSciUSA100(8):4389-94.PubMedID:12677000Tubacinsuppressesproliferationandinducesapoptosisofacutelymphoblasticleukemiacells.
Aldana-MasangkayGIetal(2011)LeukLymphoma52(8):1544-55.PubMedID:21699378TubacinkillsEpstein-Barrvirus(EBV)-BurkittlymphomacellsbyinducingreactiveoxygenspeciesandEBVlymphoblastoidcellsbyinducingapoptosis.
KawadaJetal(2009)JBiolChem284(25):17102-9.PubMedID:19386607
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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