Hello Bio/Trichostatin A/HB1402/5mg
市场价：
¥3958.50
美元价：
3045.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTrichostatinA
- ShortdescriptionPotentHDACinhibitor.InduceshiPSCsdifferentiationtocardiogeniccells.
- BIOLOGicaldescriptionPotenthistonedeacetylase(HDAC)inhibitor.InhibitsHDAC1,3,2,6,8and5(IC50valuesare0.4,1,1.3,2,90and520nMrespectively).Showsanti-proliferativeandanti-canceractions.
- AlternativenamesTSA
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptADIenamide
- MolecularWeight302.37
- Chemicalstructure
![Trichostatin A [58880-19-6]](images/hellobio/201710/hb1402.png "Trichostatin A [58880-19-6]")
- MolecularFormulaC17H22N2O3
- CASNumber58880-19-6
- PubChemidentifier444732
- SMILESC[C@H](/C=C(C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
- InChiInChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
- InChiKeyRTKIYFITIVXBLE-QEQCGCAPSA-N
- MDLnumberMFCD03848392
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinDMSO(50mM)andinethanol(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTrichostatinA
Synapsemicroarrayidentificationofsmallmoleculesthatenhancesynaptogenesis.
ShiPetal(2011)NatCommun2:510PubMedID:22027590InhibitionofmitogenesisinBalb/c-3T3cellsbyTrichostatinA.Multiplealterationsintheinductionandactivationofcyclin-cyclin-dependentkinasecomplexes.
WhartonWetal(2000)JBiolChem275(43):33981-7.PubMedID:10945992TrichostatinAisahistonedeacetylaseinhibitorwithpotentantitumoractivityagainstbreastcancerinvivo.
VigushinDMetal(2001)ClinCancerRes7(4):971-6.PubMedID:11309348
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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