Hello Bio/Tranylcypromine hydrochloride/HB1412/250mg
市场价：
¥3822.00
美元价：
2940.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameTranylcypromine hydrochloride
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Short descriptionLSD1 / MAO inhibitor. Enables reprogramming of mouse embryonic fibroblasts into iPS cells.
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Biological descriptionLysine-specific demethylase 1 (LSD1) and monoamine oxidase (MAO) inhibitor (IC50 = < 2="" µm="" for="" lsd1).="" irreversible="" inhibition="" of="" lsd1,="" inhibits="" h3k4="" demethylation.="" enables="" reprogramming="" of="" mouse="" embryonic="" fibroblasts="" into="" ips="" cells.="" shows="" antidepressant="">
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Alternative namestrans-2-phenylcyclopropylamine; 2-PCPA; Parnate
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Biological actionInhibitor
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Purity>98%
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Properties
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Chemical name(±)-trans-2-Phenylcyclopropylamine hydrochloride
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Molecular Weight169.65
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Chemical structure
![Tranylcypromine hydrochloride [1986-47-6]](images/hellobio/201710/hb1412.png "Tranylcypromine hydrochloride [1986-47-6]")
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Molecular FormulaC9H11N.HCl
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CAS Number1986-47-6
Storing and Using Your Product
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Storage instructionsroom temperature (desiccate)
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Solubility overviewsoluble in water (100mM) or DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Tranylcypromine hydrochloride
trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.
Schmidt DM et al (2007) Biochemistry 46(14) : 4408-16.PubMedID: 17367163Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.
Lee MG et al (2006) Chem Biol 13(6) : 563-7.PubMedID: 16793513Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
Li W et al (2009) Stem Cells 27(12) : 2992-3000.PubMedID: 19839055Tranylcypromine: new perspectives on an 'old' drug.
Frieling H et al (2006) Eur Arch Psychiatry Clin Neurosci 256(5) : 268-73.PubMedID: 16927039
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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