你好Bio/Tranilast/HB1201/50mg
市场价：
¥6610.50
美元价：
5085.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameTranilast
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Short descriptionTRPV2 channel inhibitor. Potent mast cell stabilizer.
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Biological descriptionTRPV2 channel inhibitor and potent mast cell stabilizer. Also inhibits angiotensin-II induced contractions (IC50 = 36 µM). Inhibits reactive oxygen species, cytokines, leukotrienes and prostaglandin release. Displays antiallergic, antiapoptotic and anti-inflammatory properties. Blood brain barrier permeable.
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Biological actionInhibitor
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Purity>99%
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Properties
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Chemical name2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
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Molecular Weight327.34
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Chemical structure
![Tranilast [53902-12-8]](images/hellobio/201710/hb1201.png "Tranilast [53902-12-8]")
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Molecular FormulaC18H17NO5
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CAS Number53902-12-8
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PubChem identifier5282230
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SMILESCOC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC
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InChiInChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
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InChiKeyNZHGWWWHIYHZNX-CSKARUKUSA-N
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MDL numberMFCD00864787
Storing and Using Your Product
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Storage instructionsRoom temperature
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Solubility overviewSoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Tranilast
Tranilast increases vasodilator response to acetylcholine in rat mesenteric resistance arteries through increased EDHF participation.
Xavier FE et al (2014) PLoS One 9(7) : e100356.PubMedID: 24992476Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II.
Jin D et al (1998) Eur J Pharmacol 361(2-3) : 199-205.PubMedID: 9865509Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells.
Hisanaga E et al (2009) Diabetes 58(1) : 174-84.PubMedID: 18984736Tranilast binds to aβ monomers and promotes aβ fibrillation.
Connors CR et al (2013) Biochemistry 52(23) : 3995-4002.PubMedID: 23679559
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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