你好Bio/Tranilast/HB1201/10mg
市场价：
¥1677.00
美元价：
1290.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTranilast
- ShortdescriptionTRPV2channelinhibitor.PotentmastcellstABIlizer.
- BIOLOGicaldescriptionTRPV2channelinhibitorandpotentmastcellstabilizer.Alsoinhibitsangiotensin-IIinducedcontractions(IC50=36µM).Inhibitsreactiveoxygenspecies,cytokines,leukotrienesandprostaglandinrelease.Displaysantiallergic,antiapoptoticandanti-inflammatoryproperties.Bloodbrainbarrierpermeable.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoicacid
- MolecularWeight327.34
- Chemicalstructure
![Tranilast [53902-12-8]](images/hellobio/201710/hb1201.png "Tranilast [53902-12-8]")
- MolecularFormulaC18H17NO5
- CASNumber53902-12-8
- PubChemidentifier5282230
- SMILESCOC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC
- InChiInChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
- InChiKeyNZHGWWWHIYHZNX-CSKARUKUSA-N
- MDLnumberMFCD00864787
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTranilast
TranilastincreasesvasodilatorresponsetoacetylcholineinratmesentericresistancearteriesthroughincreasedEDHFparticipation.
XavierFEetal(2014)PLoSOne9(7):e100356.PubMedID:24992476Tranilast,ananti-allergicdrug,possessesantagoNISTicpotencytoangiotensinII.
JinDetal(1998)EurJPharmacol361(2-3):199-205.PubMedID:9865509Regulationofcalcium-permeableTRPV2channelbyinsulininpancreaticbeta-cells.
HisanagaEetal(2009)Diabetes58(1):174-84.PubMedID:18984736Tranilastbindstoaβmonomersandpromotesaβfibrillation.
ConnorsCRetal(2013)Biochemistry52(23):3995-4002.PubMedID:23679559
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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