Hello Bio/TRAM 34/HB1058/25mg
市场价：
¥4602.00
美元价：
3540.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTRAM34
- ShortdescriptionPotent,selectiveKCa3.1channelblocker
- BIOLOGicaldescriptionPotentandselectiveKCa3.1channelblocker(IC50=18nMandKd=20nM).Exhibitsapprox200to1,500-foldlesseffectatKv1.1-1.5,Kv3.1,Kv4.2,Kir2.1andKCa1.1channels.Displaysanti-tumorpropertiesandsuppressesT-cellmitogenesis.Bloodbrainbarrierandmembranepermeable.
- BiologicalactionBlocker
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
- MolecularWeight344.84
- Chemicalstructure
![TRAM 34 [289905-88-0]](images/hellobio/201710/hb1058.png "TRAM 34 [289905-88-0]")
- MolecularFormulaC22H17ClN2
- CASNumber289905-88-0
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(50mM)orethanol(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTRAM34
TheinhibitorofCa(2+)-dependentK+channelsTRAM-34blocksgrowthofhepatocellularcarcinomacellsviadownregulationofestrogenreceptoralphamRNAandnuclearfactor-kappaB.
FreiseCetal(2013)InvestNewDrugs31(2):452-7.PubMedID:23054207TheKCa3.1blockerTRAM-34reducesinfarctionandneurologicaldeficitinaratmodelofischemia/reperfusionstroke.
ChenYJetal(2011)JCerebBloodFlowMetab31(12):2363-74.PubMedID:21750563Theintermediate-conductancecalcium-activatedpotassiumchannelKCa3.1contributestoatherogenesisinmiceandhumans.
ToyamaKetal(2008)JClinInvest118(9):3025-37.PubMedID:18688283Designofapotentandselectiveinhibitoroftheintermediate-conductanceCa2+-activatedK+channel,IKCa1:apotentialimmunosuppressant.
WulffHetal(2000)ProcNatlAcadSciUSA97(14):8151-6.PubMedID:10884437
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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