Hello Bio/Torin 2/HB2254/50mg
市场价：
¥12616.50
美元价：
9705.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTorin2
- ShortdescriptionPotent,selectivemTORinhibitor
- BIOLOGicaldescriptionPotent,selectiveandATP-competitivemTORinhibitor(IC50=2.1nMandEC50value=250pMforinhibitionofcellularmTORactivity).Shows800-foldselectivityoverPI3Kand>100-foldselectivityover~400otherproteinkinases.Showspotentantiproliferativeactivity.CausesapoptosisandautophagyandinducesG0/G1cellcyclearrest.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
- MolecularWeight432.4
- MolecularFormulaC24H15F3N4O
- CASNumber1223001-51-1
StoringandUsingYourProduct
- Storageinstructions+4°C
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTorin2
ActivityofthenovelmTORinhibitorTorin-2inB-precursoracutelymphoblasticleukemiaanditstherapeuticpotentialtopreventAktreactivation.
Simionietal(2014)Oncotarget5(20):10034-47PubMedID:25296981CharacterizationofTorin2,anATP-competitiveinhibitorofmTOR,ATM,andATR.
Liuetal(2013)CancerRes73(8):2574-86PubMedID:23436801Discoveryof9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one(Torin2)asapotent,selective,andorallyavailablemammaliantargetofrapamycin(mTOR)inhibitorfortreatmentofcancer.
Liuetal(2011)JMedChem54(5):1473-80PubMedID:21322566
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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