你好Bio/Torin 1/HB2253/50mg
市场价：
¥13689.00
美元价：
10530.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTorin1
- ShortdescriptionPotent,selectivemTORinhibitor
- BIOLOGicaldescriptionPotent,selectiveandATP-competitivemTORinhibitor(IC50valesare2and10nMatmTORC1andmTORC2respectively).Exhibits1000-foldselecticityformTORoverPI3Kand~100-foldselectivitywhencomparedto450otherproteinkinases.Impairscellgrowthandproliferationtoagreaterdegreethanrapamycin.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
- MolecularWeight607.62
- MolecularFormulaC35H28F3N5O2
- CASNumber1222998-36-8
StoringandUsingYourProduct
- Storageinstructions+4°C
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTorin1
Discoveryof1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-oneasahighlypotent,selectivemammaliantargetofrapamycin(mTOR)inhibitorforthetreatmentofcancer.
Liuetal(2010)JMedCHem53(19):7146-55PubMedID:20860370AnATP-competitivemammaliantargetofrapamycininhibitorrevealsrapamycin-resistantfunctionsofmTORC1.
Thoreenetal(2009)JBiolChem284(12):8023-32PubMedID:19150980Selectivetargetingofhumancoloncancerstem-likecellsbythemTORinhibitorTorin-1.
FrancipaneandLagasse(2013)Oncotarget4(11):1948-62PubMedID:24185040
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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