你好Bio/Torin 1/HB2253/10mg
市场价：
¥3510.00
美元价：
2700.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameTorin 1
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Short descriptionPotent, selective mTOR inhibitor
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Biological descriptionPotent, selective and ATP-competitive mTOR inhibitor (IC50 vales are 2 and 10 nM at mTORC1 and mTORC2 respectively). Exhibits 1000-fold selecticity for mTOR over PI3K and ~100-fold selectivity when compared to 450 other protein kinases. Impairs cell growth and proliferation to a greater degree than rapamycin.
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Biological actionInhibitor
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Purity>98%
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Properties
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Chemical name1-[4-[4-(1-Oxopropyl)-1-piperazinyl ]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz o[h]-1,6-naphthyridin-2(1H)-one
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Molecular Weight607.62
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Molecular FormulaC35H28F3N5O2
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CAS Number1222998-36-8
Storing and Using Your Product
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Storage instructions+4°C
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Torin 1
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.
Liu et al (2010) J Med CHem 53(19) : 7146-55PubMedID: 20860370An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
Thoreen et al (2009) J Biol Chem 284(12) : 8023-32PubMedID: 19150980Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.
Francipane and Lagasse (2013) Oncotarget 4(11) : 1948-62PubMedID: 24185040
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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