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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > Hello Bio/Torcetrapib/HB0879/50mg
商品详细Hello Bio/Torcetrapib/HB0879/50mg
Hello Bio/Torcetrapib/HB0879/50mg
Hello Bio/Torcetrapib/HB0879/50mg
商品编号: HB0879
品牌: hellobio
市场价: ¥10764.00
美元价: 8280.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Productoverview

  • Name
    Torcetrapib
  • Shortdescription
    Cholesterylestertransferproteininhibitor
  • BIOLOGicaldescription
    Cholesterylestertransferprotein(CETP)inhibitor.RaisesHDLindyslipidemia,improvesglucosehomeostasisandinsulinresistance.Inhibitsvasodilationandincreasesaldosteronetoshowhypertensiveactions.
  • Biologicalaction
    Inhibitor
  • Purity
    >99%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylicacidethylester
  • MolecularWeight
    600.47
  • Chemicalstructure
    Torcetrapib [262352-17-0]
  • MolecularFormula
    C26H25F9N2O4
  • CASNumber
    262352-17-0

StoringandUsingYourProduct

  • Storageinstructions
    roomtemperature
  • Solubilityoverview
    solubleinDMSO(50mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforTorcetrapib

  • Torcetrapibproducesendothelialdysfunctionindependentofcholesterylestertransferproteininhibition.

    ConnellyMAetal(2010)JCardiovascPharmacol55(5):459-68.
    PubMedID:20051879
  • RaisingHDLwithCETPinhibitortorcetrapibimprovesglucosehomeostasisindyslipidemicandinsulinresistanthamsters.

    BriandFetal(2014)Atherosclerosis233(2):359-62.
    PubMedID:24530763
  • UpregulatingreversecholesteroltransportwithcholesterylestertransferproteininhibitionrequirescombinationwiththeLDL-loweringdrugberberineindyslipidemichamsters.

    BriandFetal(2013)ArteriosclerThrombVascBiol33(1):13-23.
    PubMedID:23139291
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor,  NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632,  SB 431542 DAPT.